Fig. 3.
Simulation results for the kinetics of Chol redistribution in the blood at 37°C after a bolus of 10% total unesterified Chol in the aqueous compartment. The rate constants used in the kinetic model were those obtained in this work for DHE (A) or taken from literature for Chol (5, 48) (B). Time evolution of the concentration of unesterified Chol in the distinct blood compartments: aqueous phase (light blue line), HDL3 (dark green line), HDL2 (pink line), Alb (blue line), LDL (light green line), VLDL (dark blue dashed line), and Erys (red line). The y axis is the concentration at time t, C(t), divided by the equilibrium concentration before the bolus, C(0). The insets show the results obtained at longer simulation times, with the transfer of Chol from the lipoproteins to the Erys.