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. 2014 Jun;55(6):1120–1130. doi: 10.1194/jlr.M047548

Fig. 6.

Fig. 6.

LBP expression does not affect cholesterol efflux or inflammatory responses. A: Primary bone marrow-derived macrophages were treated with GW3965 (GW) overnight with (+) or without (−) LPS (10 ng/ml). Results are representative of two experiments. Values are mean ± SD. B: Western blot analysis of bone marrow-derived macrophages treated with GW3965 overnight with or without LPS (10 ng/ml). C: Bone marrow-derived macrophages treated with increasing concentration of LPS (ng/ml). Results are representative of two experiments. Values are mean ± SD. D: Cholesterol efflux assays. WT or LBP−/− macrophages were loaded with [3H]cholesterol (1.0 μCi/ml) in the presence of acyl-CoA:cholestrol O-acyltransferase inhibitor (2 μg/ml) either with DMSO or with ligand for LXR and RXR [1 μM GW3965, 50 nM LG268 (LG)]. Efflux was measured in the presence of apoA-I or HDL. Experiments were conducted in triplicate. Data are expressed as mean ± SD.