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. Author manuscript; available in PMC: 2014 May 23.
Published in final edited form as: J Comp Neurol. 2011 Dec 1;519(17):3532–3548. doi: 10.1002/cne.22721

Figure 8.

Figure 8

Expression of calbindin in the cerebellum of NFIX−/− mice. Expression of the Purkinje cell marker calbindin in the cerebellum of wild-type (A,C) and NFIX−/− (B,D) mice at P5. In the wild type, Purkinje cells were beginning to extend dendritic processes radially into the molecular layer (arrows in C). In the knockout, elaboration of dendritic processes was markedly delayed (arrowheads in D). C,D are higher magnification views of the boxed regions (lobules IV/V) in A,B, respectively. E: qPCR on wild-type and NFIX−/− P5 cerebellar tissue demonstrated significantly reduced levels of calbindin mRNA in the mutant. *P < 0.05, t-test. Scale bar = 20 µm in D (applies to B,D); 100 µm for A,C.