Figure 3.

Excitatory synaptic drive is altered in the upper cervical dorsal horn by acute neck muscle inflammation. A. Raw data showing representative spontaneous excitatory postsynaptic currents (sEPSCs, 30 s of continuous data) in SDH neurons from control, sham, and carrageenan-injected animals. sEPSCs were blocked by CNQX (10 μM, not shown). B. Stationary plots of sEPSC interevent interval (IEI) for the control, sham, and carrageenan-injected recordings shown in A. Note that these plots do not contain any time dependent trends, or tight clustering of data points that would indicate sEPSC bursting. C. Group data showing mean (left) and instantaneous (right) sEPCS frequency were similar in control, sham, and carrageenan-injected animals. D. Group data shows sEPCS amplitude (left) was significantly reduced in carrageenan-injected animals. Overlaid average sEPSC amplitude histograms (right) show a leftward shift in the distribution for carrageenan-injected animals.