Table 1. In Vitro IRE-1 RNase Inhibition by Analogues of 21b.

compd	IC50 (nM)	95% CI (nM)
21b	111	76–162
22	>20000
23	>20000
24	3051	2031–4584
25	16210	12900–20360
26	>20000
27	>20000
28	1230	704–2148
29	312	222–439
30	200	149–268
31	113	62–207
32	303	181–500
33	255	183–354
34	47	35–64
35	>20000
36	>20000
37	1718	1289–2288
38	>20000
40	4109	3099–5448
41	5644	3902–8162
42	>20000