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. Author manuscript; available in PMC: 2015 May 13.
Published in final edited form as: Circulation. 2014 Mar 5;129(19):1924–1936. doi: 10.1161/CIRCULATIONAHA.113.005610

Figure 6.

Figure 6

In vivo characterization of LV systolic function. A) Representative example of an IVC occlusion PV loop series; End-systolic elastance (Ees) (broken line) is depicted and (B) quantitative data show a significant decrease in Ees in Rbm20ΔRRM mice. C) Representative +/+, +/−, and −/− echocardiographic M-mode images and (D) quantitative analysis of the phenylephrine stress test performed in conscious mice, indicating a decrease in systolic reserve in Rbm20ΔRRM mice. Symbols: ****p<0.0001 vs. wild-type (+/+); ####p<0.0001 vs. Het (+/−). A–B: 12 +/+ mice, 12 +/− mice and 13 −/− mice; C–D: 13 +/+ mice, 12 +/− mice and 12 −/− mice.