Table 1. Citrullinated autoantigens induced by the MACPF pathway.
+, citrullinated peptides were identified; −, no citrullinated peptides were identified; +/−, potentially citrullinated (see fig. S2 for explanation).
| Citrullinated Autoantigen | Reference | Perforin | Complement | RA SF cells* |
|---|---|---|---|---|
| Actin, cytoplasmic 1/2 | (25) | + | + | + |
| Adenyl cyclase-associated protein | (40) | + | − | − |
| Aldolase | (42) | + | + | + |
| Calreticulin | (42) | + | + | + |
| Collagen type I | (41) | − | + | − |
| Elongation factor 1a | (40) | + | +/− | + |
| α-Enolase | (40) | + | + | + |
| Heat shock 60kDa protein | (42) | + | + | + |
| Heat shock 90kDa protein α/β | (44) | + | + | + |
| Histone H2A | (18) | + | + | + |
| Histone H4 | (18) | + | + | + |
| Myeloid cell nuclear differentiation antigen | (43) | + | + | + |
| Phosphoglycerate kinase 1 | (42) | + | − | + |
| PAD4 | (45) | +/− | +/− | +/− |
| Protein disulfide-isomerase | (8) | − | + | − |
| Vimentin | (39) | + | + | + |
*
Citrullination was confirmed in at least one RA SF sample