Table 4. Statistics summarized data; Discrimination between IgAN versus healthy and CKD controls for serum Gd-IgA1 and Gd-IgA1-specific IgG levels.
| Area under the ROC curve (C-statistic) | Asymptotic 95% Confidence Interval for the C-statistic | Asymptotic Significance (P-value) | AIC*** | ||
| Lower Bound | Upper Bound | ||||
| Gd-IgA1-specific IgG (IgAN vs. healthy controls) | 0.965 | 0.943 | 0.987 | 1.7E-35 | 57.4 |
| Gd-IgA1-specific IgG (IgAN vs. CKD controls) | 0.906 | 0.858 | 0.953 | 3.2E-23 | 188.5 |
| Gd-IgA1-specific IgG (IgAN vs. CKD non-immune-mediated renal disease*) | 0.973 | 0.948 | 0.999 | 1.7E-21 | 75.3 |
| Gd-IgA1-specific IgG (IgAN vs. CKD immune-mediated renal disease**) | 0.813 | 0.730 | 0.895 | 3.2E-10 | 145.2 |
| Gd-IgA1 (IgAN vs. healthy controls) | 0.800 | 0.745 | 0.855 | 9.9E-16 | 264.6 |
| Gd-IgA1 (IgAN vs. CKD controls) | 0.749 | 0.683 | 0.815 | 1.2E-09 | 246.3 |
| Gd-IgA1-specific IgA (IgAN vs. healthy controls) | 0.722 | 0.659 | 0.786 | 2.7E-09 | 295.6 |
| Gd-IgA1-specific IgA (IgAN vs. CKD controls) | 0.690 | 0.619 | 0.761 | 3.5E-06 | 266.1 |
* CKD non-immune-mediated renal disease includes diabetic nephropathy, nephrosclerosis, interstitial nephritis and Fabry's disease.
** CKD immune-mediated renal disease includes lupus nephritis, membranous nephropathy, minimal change disease, membranoproliferative glomerulonephritis, other types of non-IgAN glomerulonephritis.
***AIC: Akaike's Information Criterion.