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. 2014 May 23;9(5):e98270. doi: 10.1371/journal.pone.0098270

Figure 2. SYC-522 decreased the expression of key genes in leukemia cell lines.

Figure 2

HOXA9, MEIS1, CCND1 and BCL2L1 mRNA levels in (A) MV4-11 and (B) MOLM13 cells were analyzed by quantitative real-time PCR at 0, 3, or 6 days after SYC-522 treatment. HOXA9 and MEIS1 expression were not detectable in (C) NB4 and (D) HL-60 cells. Only CCND1 and BCL2L1 mRNA expression were analyzed in these two cell lines. The mRNA expression was normalized to the level of 18S. Values represent the fold change in mRNA levels in treated vs. control cells. Bars represent the mean ±SEM of 3 independent experiments. *: p<0.05, day 0 vs. day 3 or 6, unpaired t-test.