Figure 2. The effect of NAT administration on motor and sensory function following SCI.

A modified Tarlov score was used to assess crude motor function (A), data is expressed as the median with individual data points plotted. Whilst a significant improvement was observed at 6 days post-SCI following NAT administration, this improvement was not significantly different to vehicle on days 10 and 14 post-injury. The frequency of hindlimb movement gradually increased in both treatment groups over time (B). Whilst NAT treated animals demonstrated earlier increases in movement frequency, no significant difference was observed between groups. A similar significant decrease in sensory function was observed in both the left (C) and right (D) hindlimbs of both treatment groups. ** denotes p<0.01, *** denotes p<0.001 when compared to sham. # denotes p<0.05 compared to vehicle.