Table 3.
The association between total energy intake and breast cancer risk among sister sets by menopausal status and hormone receptor status, Breast Cancer Family Registry
| Total energy intake, kcal/d | Affected sisters (N=1,775) | Unaffected sisters (N=2,529) | OR (95% CI)a | OR (95% CI)b |
|---|---|---|---|---|
| N (%) | ||||
| Pre-menopausal women | ||||
| Q1 (< 1359.2) | 258 (22.1) | 386 (25.7) | 1.0 | 1.0 |
| Q2 (1359.2 - 1788.2) | 248 (21.2) | 371 (24.7) | 1.0 (0.8-1.3) | 0.9 (0.6-1.2) |
| Q3 (1788.2 - 2341.6) | 297 (25.4) | 353 (23.5) | 1.2 (0.9-1.6) | 1.2 (0.9-1.7) |
| Q4 (≥ 2341.6) | 367 (31.2) | 393 (26.2) | 1.5 (1.2-2.0) | 1.4 (1.0-2.0) |
| P trend =0.001 | P trend =0.01 | |||
| Post-menopausal women | ||||
| Q1 (< 1359.2) | 153 (25.3) | 331 (32.3) | 1.0 | 1.0 |
| Q2 (1359.2 - 1788.2) | 143 (23.6) | 238 (23.2) | 1.5 (1.1-2.3) | 1.6 (1.0-2.5) |
| Q3 (1788.2 - 2341.6) | 149 (24.6) | 223 (21.7) | 1.5 (1.0-2.1) | 1.2 (0.7-1.9) |
| Q4 (≥ 2341.6) | 160 (26.5) | 234 (22.8) | 1.7 (1.1-2.5) | 1.5 (0.9-2.4) |
| P trend =0.02 | P trend =0.23 | |||
| Any hormone receptor positive tumors (ER+PR+, ER+PR-, or ER-PR+) | ||||
| Q1 (< 1359.2) | 209 (23.1) | 717 (28.4) | 1.0 | 1.0 |
| Q2 (1359.2 - 1788.2) | 192 (21.2) | 609 (24.1) | 1.1 (0.9-1.5) | 1.3 (1.0-1.9) |
| Q3 (1788.2 - 2341.6) | 237 (26.2) | 576 (22.8) | 1.4 (1.1-1.9) | 1.5 (1.0-2.1) |
| Q4 (≥ 2341.6) | 266 (29.4) | 627 (24.8) | 1.7 (1.3-2.3) | 2.0 (1.4-2.8) |
| P trend <0.001 | P trend <0.001 | |||
| ER-PR- tumors | ||||
| Q1 (< 1359.2) | 56 (21.7) | 717 (28.4) | 1.0 | 1.0 |
| Q2 (1359.2 - 1788.2) | 70 (27.1) | 609 (24.1) | 1.7 (1.0-2.9) | 1.9 (1.0-3.4) |
| Q3 (1788.2 - 2341.6) | 53 (20.5) | 576 (22.8) | 1.7 (1.0-3.0) | 1.4 (0.7-2.9) |
| Q4 (≥ 2341.6) | 79 (30.6) | 627 (24.8) | 2.1 (1.2-3.6) | 1.7 (0.9-3.5) |
| P trend =0.01 | P trend =0.23 | |||
c
Adjusted for age and history of benign breast disease.
d
Additionally adjusted for education, menopausal status, BMI, average lifetime physical activity, smoking, usual alcohol consumption, age at menarche, parity, age at first live birth, ever use of oral contraceptives, and ever use of menopausal hormone therapy.