Table 4.
The joint effect of total energy intake, physical activity and body mass index on breast cancer risk, Breast Cancer Family Registry
| Total energy intake, kcal/day | Physically active c | BMI (kg/m2) | Affected sisters (N=1,775) | Unaffected sisters (N=2,529) | OR (95% CI)a | OR (95% CI)b |
|---|---|---|---|---|---|---|
| Low (<1788.2) | Yes | < 25 | 247 (13.9) | 375 (14.8) | 1.0 | 1.0 |
| High (≥1788.2) | Yes | < 25 | 345 (19.4) | 391 (15.5) | 1.4 (1.1-1.8) | 1.3 (1.0-1.8) |
| Low (<1788.2) | Yes | ≥ 25 | 167 (9.4) | 348 (13.8) | 0.8 (0.6-1.1) | 0.8 (0.6-1.1) |
| High (≥1788.2) | Yes | ≥ 25 | 320 (18.0) | 442 (17.5) | 1.3 (1.0-1.7) | 1.1 (0.8-1.5) |
| Low (<1788.2) | No | < 25 | 176 (9.9) | 239 (9.5) | 1.2 (0.9-1.6) | 1.1 (0.8-1.5) |
| High (≥1788.2) | No | < 25 | 137 (7.7) | 175 (6.9) | 1.2 (0.9-1.7) | 1.3 (0.9-1.9) |
| Low (<1788.2) | No | ≥ 25 | 212 (11.9) | 364 (14.4) | 1.0 (0.8-1.4) | 1.0 (0.7-1.5) |
| High (≥1788.2) | No | ≥ 25 | 171 (9.6) | 195 (7.7) | 1.5 (1.1-2.0) | 1.5 (1.0-2.2) |
a
Adjusted for age and history of benign breast disease.
b
Additionally adjusted for education, menopausal status, BMI, average lifetime physical activity, smoking, usual alcohol consumption, age at menarche, parity, age at first live birth, ever use of oral contraceptives, and ever use of menopausal hormone therapy.
c
Physically active was defined as having average lifetime moderate physical activity ≥2.5 hrs/wk or having average lifetime strenuous physical activity ≥1.75 hrs/wk.