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. 2014 May 23;9(5):e98317. doi: 10.1371/journal.pone.0098317

Figure 1. Immunohistochemical staining pictures of the TAZ protein expression and TAZ expression patterns in the non-RT and RT group.

Figure 1

TAZ protein expression was shown in (A) normal rectal mucosa (negative expression), (B) primary cancer (strong expression) and (C) lymph node metastasis (weak expression) (A–C, 400X). In non-RT group (D) TAZ expression was significantly higher in primary cancer compared to the distant normal mucosa (p<0.001), the adjacent mucosa (p<0.001). The expression in the lymph node metastasis TAZ expression was also significantly higher compared to the expression in distant normal mucosa (p<0.001), the adjacent mucosa (p = 0.006). However, compared to primary cancer TAZ expression in lymph node metastasis was significantly lower (p = 0.003). The RT group (E) showed significantly higher TAZ expression in the primary cancer compared to the distant and adjacent normal mucosa (p<0.001 and p<0.001 respectively). In the lymph node metastasis strong TAZ expression was significantly lower compared to the expression in primary cancer (p = 0.040). Only p-values<0.05 are presented. In primary cancer strong TAZ expression was significantly lower (p = 0.001) compared to non-RT group (F).