Table 1. List of the significant Gene Ontology annotation enriched in the differentially expressed proteins using DAVID Gene Functional Classification Tool.

Functional Annotation	p-value	Proteins (gene name)
Up-regulated proteins
GO:0030036: actin cytoskeleton organization	8.93E-06	Ezrin (EZR), Plastin-3 (PLS3), Talin-1 (TLN1), Fascin (FSCN1), Isoform 1 of Filamin-B (FLNB) Isoform 2 of Filamin-A (FLNA)
GO:0008104: protein localization	7.10E-04	Rab GDP dissociation inhibitor beta (GDI2), Ezrin (EZR), Transitional endoplasmic reticulum ATPase (VCP), Talin-1 (TLN1), 14-3-3 protein eta (YWHAH), Isoform 1 of Filamin-B (FLNB) Isoform 2 of Filamin-A (FLNA)
GO:0022614: membrane to membrane docking	0.006	Ezrin (EZR), Moesin (MSN)
GO:0007043: cell-cell junction assembly	0.023	Isoform 1 of Catenin alpha-1 (CTNNA1), Talin-1 (TLN1)
GO:0007159: leukocyte adhesion	0.036	Ezrin (EZR), Moesin (MSN)
Down-regulated proteins
GO:0015980: energy derivation by oxidation of organic compounds	2.42E-04	Isocitrate dehydrogenase [NAD] (IDH3G), Isoform 1 of NADH dehydrogenase [ubiquinone] flavoprotein 1| mitochondrial (NDUFV1), glycogen [starch] synthase| muscle isoform 2 (GYS1), Calcium-binding mitochondrial carrier protein Aralar1 (SLC25A12)
GO:0045333: cellular respiration	0.003	Isocitrate dehydrogenase [NAD] (IDH3G), Isoform 1 of NADH dehydrogenase [ubiquinone] flavoprotein 1| mitochondrial (NDUFV1), Calcium-binding mitochondrial carrier protein Aralar1 (SLC25A12)
GO:0055085: transmembrane transport	0.012	Isoform SERCA1B of Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1), ADP/ATP translocase 2 (SLC25A5) Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11), Calcium-binding mitochondrial carrier protein Aralar1 (SLC25A12)