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. Author manuscript; available in PMC: 2014 May 23.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2012 Aug 29;39(5):543–560. doi: 10.1007/s10928-012-9267-z

Table 1. Parameter values used for simulating the time courses of model variables from Example 1.

Parameter Description Value Reference
kret = kup (day−1) Endosome uptake and recycle 1.03 [18]
kdeg (day−1) First-order elimination 0.43 [18]
Rtot (nM) Total FcRn receptor 1.22 [18]
VE = Vc (mL kg−1) Volume of distribution 66.9 [18]
CA0 (nM) Baseline for free endogenous IgG 14700 [18]
KDA (nM) Dissociation constant for endogenous IgG 4.8 [18]
InA0 (nM h−1) Zero-order production for endogenous IgG 108 Calculated
KDB (nM) Dissociation constant for exogenous IgG 4.8, 0.48, 0.048