Table 1. Parameter values used for simulating the time courses of model variables from Example 1.
Parameter | Description | Value | Reference |
---|---|---|---|
kret = kup (day−1) | Endosome uptake and recycle | 1.03 | [18] |
kdeg (day−1) | First-order elimination | 0.43 | [18] |
Rtot (nM) | Total FcRn receptor | 1.22 | [18] |
VE = Vc (mL kg−1) | Volume of distribution | 66.9 | [18] |
CA0 (nM) | Baseline for free endogenous IgG | 14700 | [18] |
KDA (nM) | Dissociation constant for endogenous IgG | 4.8 | [18] |
InA0 (nM h−1) | Zero-order production for endogenous IgG | 108 | Calculated |
KDB (nM) | Dissociation constant for exogenous IgG | 4.8, 0.48, 0.048 |