Table 3.
Large Region | Region | Mean LGI (SE)a | Effect sizes for contrasts to controls Cohen's d | |||||
---|---|---|---|---|---|---|---|---|
Controls (HC) n=243 | All Relatives (Rel) n=300 | Axis IIA Relatives (AxIIA) n=33 | Probands (Prob) n=388 | |||||
HC-Rel | HC-AxIIA | HC-Prob | ||||||
Cingulate | Left Caudal Anterior Cingulate | 1.73 (0.01) | 1.72 (0.01) | 1.70 (0.02) | 1.71 (0.01) | 0.087 | 0.221 | 0.175** |
Left Posterior Cingulate | 1.77 (0.01) | 1.76 (0.01) | 1.76 (0.02) | 1.74 (0.01) | 0.017 | 0.074 | 0.146$ | |
Right Caudal Anterior Cingulate | 1.78 (0.01) | 1.78 (0.01) | 1.77 (0.02) | 1.76 (0.01) | 0.022 | 0.155 | 0.187** | |
Right Posterior Cingulate | 1.81 (0.01) | 1.82 (0.01) | 1.80 (0.02) | 1.79 (0.01) | −0.010 | 0.146 | 0.179* | |
Composite | 1.78 (0.01) | 1.78 (0.01) | 1.76 (0.02) | 1.76 (0.01) | 0.020 | 0.247$ | 0.130* |
Values adjusted for age, sex, site, race, lithium usage, and intracranial volume
p < 0.06
p<0.05
p<0.01
*** p<0.001 (All p-values reflect Benjamini-Hochberg adjustment)