Effective diffusion constant, D, for coions (red), counterions (blue), and neutral diffusers (black) for a unit cell with a 12.5 [Å] negatively charged, spherical protein. Attractive counterion/protein interactions have faster diffusion relative to neutral and negatively charged diffusers. Inclusion of attractive van der Waals interactions (+VDW) through the HSE with a DLVO potential increases the effective diffusion constants.