Table 3.
Cell surface antigen expression by PMLC subpopulations in BAL fluid following LPS inhalation
| ANTIGEN | EXPRESSED BY | rPMLC | iPMLC |
|---|---|---|---|
|
Ki67 |
Proliferating cells |
19.0 [18.5 – 42.1] |
2.1 [0.7 – 8.4]** |
|
CD71 (transferrin receptor) |
Mature macrophages |
20.3 [15.7 – 31.7] |
2.8 [1.5 – 3.6]*** |
|
CD206 (mannose receptor) |
Alternatively activated macrophages |
86.7 [72.8 – 97.9] |
61.9 [40.6 – 73.9]* |
|
CD163 |
Alternatively activated macrophages |
92.2 [56.4 – 98.5] |
69.6 [29.1 – 91.9]NS |
| 25 F9 | Mature macrophages | 89.8 [73.1 – 97.0] | 57.3 [14.4 – 97.5]NS |
Data are expressed as median [interquartile range (IQR)] % of cells expressing each marker; n = 12; statistical analysis by Mann Whitney U test; NSnon-significant, *P < 0.05, **P < 0.005, ***P < 0.0005.