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. 2014 May 21;14:278. doi: 10.1186/1471-2334-14-278

Table 5.

Adjusted incidence rate ratios and 95% confidence intervals for factors associated with AIDS-related events, non-AIDS-related events, and deaths (ANRS CO3 Aquitaine and IPEC/FIOCRUZ cohorts combined, 2000–2008)

 
 AIDS-related
 Non-AIDS
    All Bacterial Psychiatric Hepatic
Cohort: IPEC (vs. Aquitaine)
 1.09 (0.91, 1.3)
 0.53 (0.46, 0.62)
 1.17 (0.94, 1.47)
 0.37 (0.24, 0.55)
 0.78 (0.52, 1.17)
Calendar year (per year)
 1.03 (0.99, 1.06)
 1.02 (1.0, 1.05)
 1.03 (1.0, 1.07)
 1.04 (0.98, 1.09)
 1.05 (0.98, 1.12)
Age (in years)
  
  
  
  
  
<30 years
 1 (Ref.)
 1 (Ref.)
 1 (Ref.)
 1 (Ref.)
 1 (Ref.)
30-39
 0.95 (0.72, 1.26)
 1.05 (0.83, 1.33)
 1.34 (0.98, 1.83)
 1.28 (0.76, 2.17)
 0.8 (0.39, 1.65)
40-49
 0.81 (0.61, 1.08)
 1.12 (0.88, 1.44)
 1.18 (0.85, 1.64)
 1.18 (0.7, 2.01)
 1.52 (0.78, 2.99)
50-59
 0.59 (0.42, 0.83)
 1.24 (0.94, 1.65)
 1.13 (0.78, 1.64)
 0.95 (0.5, 1.78)
 1.48 (0.67, 3.28)
≥60
 0.93 (0.61, 1.4)
 2.16 (1.58, 2.97)
 1.9 (1.24, 2.89)
 1.14 (0.54, 2.38)
 3.09 (1.13, 8.49)
Sex: Female (vs. Male)
 0.9 (0.76, 1.07)
 1.01 (0.88, 1.15)
 0.95 (0.79, 1.15)
 1.06 (0.81, 1.37)
 0.98 (0.63, 1.52)
IDU: Yes (vs. No)
 1.03 (0.78, 1.36)
 1.42 (1.18, 1.7)
 1.01 (0.75, 1.34)
 3.14 (2.29, 4.3)
 1.49 (0.89, 2.49)
CD4 cell count (cells/mm3)
  
  
  
  
  
>500
 1 (Ref.)
 1 (Ref.)
 1 (Ref.)
 1 (Ref.)
 1 (Ref.)
351-500
 3.47 (2.19, 5.51)
 1.28 (1.07, 1.53)
 1.24 (0.95, 1.61)
 0.96 (0.67, 1.38)
 2.42 (1.44, 4.08)
201-350
 9.05 (5.91, 13.88)
 2.25 (1.89, 2.67)
 1.85 (1.43, 2.4)
 1.98 (1.44, 2.73)
 4.87 (2.97, 7.99)
51-200
 31.83 (20.81, 48.71)
 4.34 (3.59, 5.24)
 3.94 (2.95, 5.26)
 2.59 (1.76, 3.79)
 9.52 (5.56, 16.29)
≤50
 111.45 (70.13, 177.11)
 10.99 (8.66, 13.94)
 9.14 (6.37, 13.12)
 4.98 (2.96, 8.37)
 22.31 (11.27, 44.15)
HIV viral load (copies/mL)
  
  
  
  
  
≤400
 1 (Ref.)
 1 (Ref.)
 1 (Ref.)
 1 (Ref.)
 1 (Ref.)
401-3000
 1.58 (1.14, 2.17)
 1.3 (1.09, 1.54)
 1.41 (1.09, 1.83)
 1.08 (0.75, 1.57)
 1.28 (0.76, 2.17)
3001-10000
 1.6 (1.11, 2.29)
 1.45 (1.18, 1.76)
 1.12 (0.83, 1.52)
 1.87 (1.25, 2.81)
 1.71 (0.86, 3.4)
10001-100000
 2.3 (1.76, 3.01)
 1.76 (1.5, 2.06)
 1.96 (1.54, 2.49)
 2.02 (1.44, 2.84)
 1.53 (0.96, 2.43)
>100000
 4.39 (3.33, 5.8)
 2.61 (2.15, 3.16)
 2.79 (2.12, 3.68)
 2.89 (1.93, 4.33)
 2.18 (1.21, 3.92)
≤1 year since HIV + test: Yes (vs. No)
 3.87 (3.19, 4.71)
 1.99 (1.69, 2.35)
 1.51 (1.16, 1.97)
 1.04 (0.65, 1.67)
 2.74 (1.84, 4.1)
On cART: Yes (vs. No)
 2.15 (1.23, 3.74)
 2.5 (1.82, 3.44)
 1.58 (1.04, 2.41)
 2.21 (1.12, 4.38)
 3.72 (1.5, 9.2)
Hepatitis B positive (vs. not)
 1.03 (0.77, 1.39)
 1.17 (0.93, 1.47)
 1.23 (0.9, 1.68)
 0.92 (0.57, 1.5)
 1.93 (1.16, 3.18)
Hepatitis C positive (vs. not)
 0.95 (0.74, 1.23)
 1.7 (1.45, 2.0)
 1.91 (1.52, 2.4)
 1.73 (1.29, 2.32)
 5.18 (3.29, 8.14)
 
 Non-AIDS
 Death
 
 Viral
 Neurological
 Cardiovascular
 Parasitic
  
Cohort: IPEC (vs. Aquitaine)
 0.52 (0.38, 0.7)
 0.06 (0.03, 0.12)
 1.13 (0.76, 1.68)
 0.17 (0.09, 0.3)
 1.01 (0.79, 1.28)
Calendar year (per year)
 0.95 (0.9, 1.0)
 0.96 (0.9, 1.02)
 1.01 (0.94, 1.1)
 1.04 (0.98, 1.11)
 1 (0.96, 1.04)
Age (in years)
  
  
  
  
  
<30 years
 1 (Ref.)
 1 (Ref.)
 1 (Ref.)
 1 (Ref.)
 1 (Ref.)
30-39
 0.93 (0.6, 1.44)
 1.1 (0.55, 2.21)
 0.93 (0.39, 2.19)
 1.07 (0.59, 1.94)
 1.76 (0.92, 3.35)
40-49
 0.82 (0.51, 1.31)
 1.41 (0.67, 2.93)
 1.72 (0.74, 4)
 0.89 (0.48, 1.65)
 2.18 (1.15, 4.14)
50-59
 0.76 (0.44, 1.32)
 1.55 (0.72, 3.33)
 2.4 (0.99, 5.81)
 0.85 (0.43, 1.67)
 3.25 (1.69, 6.25)
>60
 0.94 (0.47, 1.85)
 3.13 (1.41, 6.97)
 5.27 (2.14, 12.93)
 1.19 (0.42, 3.35)
 6.55 (3.32, 12.92)
Sex: Female (vs. Male)
 1.26 (0.98, 1.62)
 1.04 (0.74, 1.47)
 0.94 (0.65, 1.35)
 1.2 (0.85, 1.69)
 0.66 (0.51, 0.85)
IDU: Yes (vs. No)
 1.07 (0.77, 1.48)
 2.01 (1.29, 3.12)
 1.55 (0.97, 2.46)
 1.08 (0.71, 1.64)
 1.29 (0.93, 1.78)
CD4 cell count (cells/mm3)
  
  
  
  
  
>500
 1 (Ref.)
 1 (Ref.)
 1 (Ref.)
 1 (Ref.)
 1 (Ref.)
351-500
 0.81 (0.55, 1.18)
 1.48 (0.94, 2.33)
 2.00 (1.23, 3.24)
 1.79 (0.85, 3.75)
 1.44 (0.99, 2.08)
201-350
 1.76 (1.25, 2.48)
 2.3 (1.52, 3.46)
 2.06 (1.22, 3.47)
 3.82 (1.88, 7.76)
 2.25 (1.6, 3.18)
51-200
 2.8 (1.9, 4.11)
 5.76 (3.58, 9.26)
 4.64 (2.66, 8.12)
 11.73 (5.9, 23.32)
 6.33 (4.5, 8.89)
≤50
 9.71 (6.07, 15.52)
 13.6 (7.55, 24.49)
 15.9 (8.13, 31.28)
 29.59 (13.83, 63.28)
 27.32 (18.44, 40.47)
HIV viral load (copies/mL)
  
  
  
  
  
≤400
 1 (Ref.)
 1 (Ref.)
 1 (Ref.)
 1 (Ref.)
 1 (Ref.)
401-3000
 1.38 (0.94, 2.02)
 1.51 (0.98, 2.33)
 0.91 (0.52, 1.59)
 2.22 (1.11, 4.48)
 0.91 (0.64, 1.31)
3001-10000
 1.65 (1.07, 2.53)
 1.91 (1.23, 2.97)
 1.13 (0.6, 2.1)
 3.09 (1.52, 6.31)
 1.03 (0.68, 1.56)
10001-100000
 2.52 (1.83, 3.46)
 1.63 (1.11, 2.38)
 1.18 (0.77, 1.8)
 4.88 (2.9, 8.21)
 1.08 (0.81, 1.44)
>100000
 3.13 (2.1, 4.65)
 2.49 (1.59, 3.9)
 1.15 (0.67, 1.99)
 8.03 (4.51, 14.29)
 1.49 (1.07, 2.09)
≤1 year since HIV + test: Yes (vs. No)
 2.72 (1.93, 3.83)
 1.17 (0.67, 2.03)
 1.67 (0.96, 2.93)
 4.51 (3.14, 6.47)
 0.85 (0.53, 1.37)
On cART: Yes (vs. No)
 2.45 (1.3, 4.6)
 8.3 (1.95, 35.33)
 3.86 (1.17, 12.8)
 7.62 (1.75, 33.26)
 0.85 (0.5, 1.47)
Hepatitis B positive (vs. not)
 0.98 (0.61, 1.59)
 1.07 (0.6, 1.91)
 1.05 (0.61, 1.8)
 1.31 (0.73, 2.37)
 1.96 (1.44, 2.66)
Hepatitis C positive (vs. not) 1.11 (0.82, 1.51) 1.02 (0.65, 1.58) 1.31 (0.89, 1.94) 1.26 (0.85, 1.87) 1.79 (1.34, 2.38)

Bold indicates statistically significant results.

IDU injection drug use. cART combination antiretroviral therapy.