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. 2014 Mar 20;13(3):457–467. doi: 10.1111/acel.12202

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© 2014 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Genetic mutations effecting acetic acid levels do not alter, chronological lifespan, and pH. (A) The glucose metabolism pathway leading to ethanol and acetate generation. Chronological survival (B) and extracellular acetic acid concentration (C) of wild-type (DBY746), ady2∆, pdc6∆, and acs1∆ mutants (B, n = 5–9; C, n = 3–7).Chronological survival (D) and extracellular acetic acid concentration (E) of wild-type (BY4741) and ald6∆ mutants (n = 3). The pH of conditioned media during chronological aging of DBY746 (F), BY4741 (G), wild-type cells and their derivatives.