Figure 5.

Increased long-term self-renewal capacity and multilineage potential in Smurf2-deficient hematopoietic stem cells (HSCs). Bone marrow (BM) cells of wild-type (+/+) and Smurf2^T/T (T/T) mice are used as donors in serial BM transplantation. (A) Kaplan–Meier survival curves of recipient mice receiving BM from 2-month-old donors in the 4th transplantation cycle. Two independent serial transplantation experiments using male (left panel) or female (right panel) donors are shown. (B) Kaplan–Meier survival curves of recipient mice receiving BM from 24-month-old donors in the 4th transplantation cycle. The log-rank test is used for statistical analysis.