Figure 4.

One-month exposure to rapamycin impairs glucose tolerance. UM-HET3 mice, at 4 months of age, were placed onto diet containing the indicated doses of rapamycin at UT and evaluated 1 month later for responses to intraperitoneal glucose injection. N = 5 of each treatment group for each sex. The upper panels show mean ± SEM for plasma glucose at the indicated times. The bottom panels show integrated area under the glucose curve as mean ± SEM; bars that share a letter code are not statistically significant by t-test.