Table 1.
Survival statistics pooled across sites
| Median | Median increase | Log-rank P-value | N | 90th %ile age | 90th %ile increase | Wang/Allison | |
|---|---|---|---|---|---|---|---|
| Males | |||||||
| Controls | 807 | 300 | 1094 | ||||
| Rapamycin (4.7) | 834 | 3 | 0.19 | 156 | 1162 | 6 | 0.23 |
| Rapamycin (14) | 909 | 13 | 0.0015 | 156 | 1180 | 8 | 0.003 |
| Rapamycin (42) | 992 | 23 | <0.0001 | 156 | 1185 | 8 | 0.004 |
| Females | |||||||
| Controls | 896 | 280 | 1159 | ||||
| Rapamycin (4.7) | 1043 | 16 | <0.0001 | 136 | 1218 | 5 | <0.0001 |
| Rapamycin (14) | 1086 | 21 | <0.0001 | 136 | 1285 | 11 | <0.0001 |
| Rapamycin (42) | 1132 | 26 | <0.0001 | 136 | 1282 | 11 | <0.0001 |
Comment: median increase and 90th percentile increase are with respect to the corresponding values in the pooled controls of the same sex. Log-rank P-values were calculated with stratification by site. Wang/Allison test P-values (Wang et al., 2004) used the Fisher’s exact test to compare the counts of live and dead mice, added across the three test sites, at the site-specific age of 10% survival for the relevant joint distribution.