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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Cell Signal. 2014 Mar 15;26(7):1392–1399. doi: 10.1016/j.cellsig.2014.02.023

Fig. 3.

Fig. 3

KIBRA in Hippo pathway. (A) In Drosophila, kibra forms complexes with Mer and Ex and functions upstream of the Hpo-Sav complex; kibra also interacts with Wts and Pez (PTPN14). (B) In human cells, KIBRA associates with multiple proteins and regulates the Hippo-YAP signaling activity independent of Mst1/2. Arrows and blunted ends indicate positive (activation) and negative regulation (inhibition), respectively. Dashed arrow indicates unknown interaction.