Conceptual Model of the Association between Caregiving and Health-Related Quality of Life, by Study Aim. Using data from the Survey of the Health of Wisconsin, 2008–2010 (n=1,364), this study aimed to determine if and to what extent 1) global stress and HRQoL differed between caregivers and non-caregivers; 2) global stress mediated the relationship between caregiving status and HRQoL; and 3) caregiver strain was associated with worse HRQoL, and whether this association remained after accounting for global stress.