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. 2014 Jan 9;13(3):431–440. doi: 10.1111/acel.12193

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© 2014 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Integrin-linked kinase (ilk) heterozygous mutants have increased lifespan. The lifespan of ilk^54-^wCS/+ (red), mys^XG43/w^CS (blue), and w^CS (control, black) flies was examined. ilk⁵⁴ and mys^XG43 were introgressed into the w^CS wild-type background for six generations. Top, the survival curves of female w^CS (mean 32 days, N = 222), ilk^54-^wCS/+ (mean 51 days, N = 217), and mys^XG43/+ (mean 62 days, N = 222) flies. Bottom, the survival curves of male w^CS (mean 36 days, N = 222) and ilk^54-^wCS/+ (mean 59 days, N = 207) flies. As mys is X-linked and hemizygous mys/Y flies are lethal, males could not be examined. Both male and female ilk^54-^wCS/+ flies, and female mys^sXG43/+ flies lived longer than the controls (w^CS). For statistics, see Table 1. Survival curves of trial 2 in Table 1 are shown.