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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Curr Drug Targets. 2014 Jan;15(1):2–16. doi: 10.2174/1389450114666140106095151

Figure 2. BRCA1 and BRCA2 structure and functions.

Figure 2

Schematic representations of BRCA1 (A) and BRCA2 (B) structural motifs, interacting proteins, and corresponding kinase phosphorylation sites. Both BRCA1 and BRCA2 regulate DNA double-strand breaks repair; however, BRCA1 is also involved in mediating ubiquitination and transcriptional control.