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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Curr Drug Targets. 2014 Jan;15(1):2–16. doi: 10.2174/1389450114666140106095151

Figure 3. Representation of tumor suppressor gene therapy model.

Figure 3

(A) For patients with hereditary retinoblastoma, one copy of the mutated or deleted RB gene is inherited from their parents (the first hit). (B) Acquisition of a second hit, a somatic mutation, causes “loss of heterozygosity” and retinoblastoma. (C) Replacement of the mutated or deleted RB with a normal RB cDNA inhibits tumor growth.