Figure 5. IBR2 inhibits tumor growth by disrupting interaction between RAD51 and BRC repeats.
(A) Structures of IBR compounds (B6 is the negative compound) that disrupt RAD51/BRC repeats interaction. (B) IBR2-RAD51 docking model. IBR2 is shown in ball-and-stick model and colored by hydrophobicity. (Figure adapted from (194))