Figure 7.

Most human recent positive selection occurs in regulatory sequences. The filled circles and squares show the correlation coefficients of the absolute values of iHS with the density of regulatory and coding sequence density, respectively, controlling for recombination and average pairwise diversity (Methods). The open circles and squares show partial correlations. For instance, an open circle shows partial correlation between absolute values of iHS and regulatory density controlling for coding density (also controlling for recombination and average pairwise diversity). All correlations are Spearman’s rank correlations or partial correlations. Correlation coefficients >0.05 are all highly significant (P < 2 × 10⁻¹⁶).