Table 2.

Patterns of mutual exclusivity and co-occurrence of driver genes and microRNA machinery gene alteration in The Cancer Genome Atlas consortium data for the breast invasive carcinoma dataset (N = 463).

Occurrence pattern	miRNA machinery gene	Driver genea	p Value
MUTUALLY EXCLUSIVE OCCURRENCE
	AGO2	CTCF	0.005
	TRBP	KMT2C	0.0019*
		PIK3R1	0.03*
CO-OCCURRENCE
	AGO2	PTEN	0.0047
		TP53	0.00
	XPO5	TP53	0.0002
		GATA3	0.0001
	DICER1	MAP3K1	0.007
		CTCF	0.01

^aDriver genes are those with the highest incidence of alterations in a given dataset. *Strong tendency toward mutual exclusivity 0 < odds ratio < 0.1. TCGA data obtained through cBioPortal (80, 81).