Table 3.
Expression levels of microRNA machinery genes in human tumors.
| miRNA machinery gene | Alteration type | Cancer type (reference) |
|---|---|---|
| Drosha | Up-regulation | BCC (82), SCC (82, 83), smooth muscle neoplasm (84) |
| Down-regulation | Ovarian cancer (85), neuroblastoma (86), endometrial cancer (87), NPC (88), breast cancer (89), gallbladder adenocarcinoma (90) | |
| DGCR8 | Up-regulation | BCC (91), SCC (91), CRC (92), gastrointestinal cancer (93), ovarian cancer (94) |
| XPO5 | Up-regulation | Urothelial carcinoma (95), breast cancer (96) |
| Mutant | Non-small-cell lung cancer (19), renal cell carcinoma (79), CRC (97, 98), multiple myeloma (99) | |
| Dicer | Up-regulation | SCC (67), prostate cancer (100), smooth muscle neoplasm (84) |
| Down-regulation | Neuroblastoma (86), breast cancer (101), endometrial cancer (87), NPC (88), transitional cell carcinoma (102), gallbladder adenocarcinoma (90) | |
| AGO2 | Up-regulation | Prostate cancer (100), epithelial skin cancer (91), GC (103), hepatocellular carcinoma (104) |
| Down-regulation | Lung adenocarcinoma (105), melanoma (106) | |
| Mutant | GC (97), CRC (97), breast cancer (107) | |
| TRBP | Up-regulation | Prostate cancer (100), diffuse large B-cell lymphoma (108), adrenocortical carcinoma (109) |
| Mutant | CRC cells (105), endometrial cancer cells (105) |
BCC, basal cell carcinoma; GC, gastric cancer; NPC, nasopharyngeal carcinoma; SCC, squamous cell carcinoma.