Table 3.
Substitutions in the peptide-binding site (PBS) associated with outcome (3, 24, 32) in 13 frequent HLA-C mismatches as reported in Ref. (28).
| HLA-C MM | Nb pata | Residues in the PBS |
Nb | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 9 | 97 | 99 | 116 | 152 | 156 | 163 | MMb | ||
| 03:03–03:04 | 22 | – | – | – | – | – | – | – | 0 |
| 07:01–07:02 | 14 | – | – | Y/S | – | – | – | – | 1 |
| 15:02–14:02 | 13 | Y/S | R/W | Y/F | L/S | – | L/R | – | 5 |
| 04:01–16:01 | 10 | S/Y | R/W | F/Y | F/S | E/A | R/Q | – | 6 |
| 01:02–02:02 | 9 | F/Y | W/R | C/Y | Y/S | – | R/W | – | 5 |
| 05:01–07:04 | 8 | Y/D | – | – | – | E/A | R/D | – | 4 |
| 07:02–03:04 | 8 | D/Y | – | S/Y | S/Y | A/E | – | T/L | 5 |
| 14:02–01:02 | 7 | S/F | – | F/C | S/Y | – | – | – | 3 |
| 12:03–07:01 | 9 | Y/D | – | W/R | – | E/A | W/L | – | 4 |
| 02:02–15:02 | 7 | – | – | – | S/L | – | W/L | E/T | 3 |
| 12:03–04:01 | 5 | Y/S | W/R | Y/F | S/F | – | W/R | – | 6 |
| 03:04–04:01 | 5 | Y/S | – | Y/F | – | – | L/R | L/T | 4 |
| 01:02–15:02 | 5 | F/Y | W/R | C/Y | Y/L | – | R/L | – | 5 |
aNumber of patient/donor pairs.
bNumber of mismatched residues in the PBS (out of the seven key amino acids reported to be associated with outcome).