Figure 2.

Schematic of the eye with anatomical sites relevant for the development of POAG in which sGC is expressed indicated. Sections through retinal ganglion cells, ciliary muscle and a retinal arteriole from a human eye were stained for sGCα₁ (green), α-smooth muscle actin (red), and/or DAPI nucleic acid stain (blue). Both sGCα₁ and sGCβ₁ (not shown) co-localized with a-smooth muscle actin in ciliary muscle and the smooth muscle cell layer of a retinal arteriole (yellow in merged images). In addition, sGCα₁ and sGCβ₁ (not shown) expression was detected histologically in the outer nuclear layer, inner nuclear layer, and ganglion cell layer of the retina.