Table 1.

Genes involved in the NALCN channelosome and their known roles.

Gene	Cytogenetic location	Coordinates (GRCh37 genome assembly)	Gene product function	References
NALCN	13q33.1	101,706,129–102,068,812	Ion channel	Lu et al., 2007, 2009; Swayne et al., 2009
UNC-80	2q34	210,636,716–210,864,023	Scaffold protein for the SFKs and UNC-79	Wang and Ren, 2009; Lu et al., 2010
			Neuronal localization	Jospin et al., 2007; Yeh et al., 2008
UNC-79	14q32.12	93,799,565–94,174,222	Expression level of NALCN and UNC-80	Humphrey et al., 2007; Yeh et al., 2008; Lu et al., 2010
			Neuronal localization	Yeh et al., 2008
NLF-1	13q33.3	107,822,318–108,519,083	Expression level of NALCN	Xie et al., 2013
CHRM3	1q43	239,549,876–240,078,750	NALCN activator	Swayne et al., 2009
SRC	20q12-q13	35,973,088–36,033,835	Tyrosine kinase	Lu et al., 2009; Swayne et al., 2009