Table 3.
Possible implications of the NALCN channel complex in diseases.
| Disease | Gene | Reference |
|---|---|---|
| Infantile neuroaxonal dystrophy (INAD) | NALCN | Koroglu et al., 2013 |
| Autosomal-recessive syndrome with severe hypotonia, speech impairment, and cognitive delay | NALCN | Al-Sayed et al., 2013 |
| Cervical dystonia | NALCN | Mok et al., 2013 |
| Cancer | ||
| Pancreas | NALCN | Biankin et al., 2012 |
| Non-small cell lung | NALCN, UNC-80 | Lee et al., 2013 |
| Tumor-derived endothelial cells | NLF-1 | McGuire et al., 2012 |
| Glioblastoma | NALCN, NLF-1 | Fontanillo et al., 2012 |
| Psychiatric disorders | ||
| Bipolar disorder | NALCN, UNC-79 | Baum et al., 2008; Askland et al., 2009; Wang et al., 2010 |
| Schizophrenia | NALCN | Wang et al., 2010 |
| Depression | NLF-1 | Terracciano et al., 2010 |
| Attention-deficit/hyperactivity disorder with conduct disorder | NLF-1 | Anney et al., 2008 |
| Epilepsy | UNC-80 | Ratnapriya et al., 2010; EPICURE Consortium et al., 2012 |
| Autism | UNC-80 | Iossifov et al., 2012 |
| 13q syndrome | NALCN, NLF-1 | Brown et al., 1995; Kirchhoff et al., 2009; Huang et al., 2012; Lalani et al., 2013 |
| Alzheimer's disease | UNC-80 | Scott et al., 2003 Lee et al., 2008; Grupe et al., 2007 |
| UNC-79 | ||
| Alcoholism | NALCN | Wetherill et al., 2014 Lind et al., 2010 Nurnberger et al., 2001; Schuckit et al., 2001 |
| UNC-79 | ||
| UNC-80 | ||
| Restless legs syndrome | NALCN | Balaban et al., 2012 |
| Primary biliary cirrhosis | NLF-1 | Hirschfield et al., 2009 |
| Hypertension | NLF-1 | Adeyemo et al., 2009 |
| Polyglutamine disorders | NLF-1 | Whan et al., 2010 |