Table 4.
Symptoms in fatal familial insomnia patients (n=23) stratified by time of occurrence
| Symptom/sign | Frequency* | Time of occurrence (d) | Frequency weighted by time |
|---|---|---|---|
| Loss of weight (<10 kg) | 19 | 14 | 1.357 |
| Husky voice | 5 | 14 | 0.357 |
| Psychiatric | 20 | 84 | 0.238 |
| Sleeping disturbances | 22 | 107 | 0.206 |
| Vegetative | 19 | 124 | 0.153 |
| Visual | 16 | 157 | 0.102 |
| Cognitive/mnestic | 20 | 207 | 0.097 |
| Frontal lobe signs | 2 | 22 | 0.091 |
| Myoclonus | 16 | 226 | 0.071 |
| Ataxia | 19 | 273 | 0.070 |
| Bulbar | 10 | 145 | 0.069 |
| Extrapyramidal | 5 | 78 | 0.064 |
| Spatial disorientation | 15 | 260 | 0.058 |
| Dysarthria | 14 | 259 | 0.054 |
| Pyramidal | 10 | 205 | 0.049 |
*Number of patients with positive symptom/sign.