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Summary of the LC-MS analysis of the reaction progress.
| Entry | Conditions | Conversion (%) | ||
|---|---|---|---|---|
| 5 min | 30 min | 4 h | ||
| 1 | 95% TFA in H2O | 100 | – | – |
| 2 | 50% TFA in H2O | 100 | – | – |
| 3 | 10% TFA in H2O/CH3CN (1:1, v/v) | – | 63 | 100 |
| 4 | 5% TFA in AcOH/H2O (1:1, v/v) | – | 85 | 100 |
| 5 | 1% TFA in AcOH/H2O (1:1, v/v) | – | 20 | 67 |
| 6 | 5% TFA in H2O/CH3CN (1:1, v/v) | – | 40 | 100 |
| 7 | 1% TFA in H2O/CH3CN (1:1, v/v) | – | 7 | 42 |
