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. 2014 May 22;8:100. doi: 10.3389/fnsys.2014.00100

Figure 7.

Figure 7

Bicuculline and strychnine increase tactile responses of Pr5 neurons. (A) PSTHs of a representative neuron in control conditions and after iontophoretic application of bicuculline in the Pr5 nucleus (10 mM; 50 nA; upper histograms). Bicuculline blocked GABAergic inhibition and the tactile responses increased. A similar effect was observed after application of the glycinergic receptor antagonist strychnine (100 mM; 100 nA; lower histograms). (B) plot of the mean tactile responses before (C) and 1–5 min after the application of an SI stimulation train. SI cortical stimulation inhibited Pr5 tactile responses after application of saline solution (n = 12; black circles), but the effect was blocked by bicuculline (n = 9; red squares). However, strychnine application did not affect the long-lasting cortical-evoked inhibition (n = 7; blue triangles). * P < 0.05, ** P < 0.01 statistical significance after cortical stimulation train with respect to control values.