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Effect of MK-801 (0.178 mg/kg, S.C.) on glutamate release in the cortex of freely moving OX1 receptor knockout mice and wild-type mice (within subject study design). Real-time measurements of glutamate were conducted before and after compound administration (MK-801 was administered at t = 0). Results are expressed as change in glutamate concentrations as mean ± s.e.m. MK-801 response in OX1 receptor knockout mice was attenuated compared to wild-type mice (p = 0.042).
