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. 2014 May 22;5:233. doi: 10.3389/fimmu.2014.00233

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Copyright © 2014 Haselmayer, Camps, Muzerelle, El Bawab, Waltzinger, Bruns, Abla, Polokoff, Jond-Necand, Gaudet, Benoit, Bertschy Meier, Martin, Gretener, Lombardi, Grenningloh, Ladel, Petersen, Gaillard and Ji.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MSC2360844 and MSC2364588 inhibit BCR-induced signaling and activation of CD19⁺ B cells in healthy donors and SLE patients. (A) Peripheral blood from healthy donors were collected in heparinized tubes and stimulated with anti-IgM for 5 min. Intracellular pAkt gated on CD19⁺ cells were analyzed by flow cytometry. (B) Peripheral blood from healthy donors were collected in heparinized tubes and stimulated with anti-IgM for 18 h. CD69 up-regulation on CD19⁺ cells were analyzed by flow cytometry. Mean fluorescent intensity (MFI) from basal and stimulated conditions without inhibitor were used as 100% of activity. Data shown are mean ± SEM and are representative for at least five healthy donors. (C) PBMCs from two SLE patients were stimulated with anti-IgM for 18 h. CD69 up-regulation on CD19⁺ cells were analyzed by flow cytometry. Mean fluorescent intensity (MFI) from basal and stimulated conditions without inhibitor were used as 100% of activity.