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Cross-resistance data for the most frequent resistant hepatitis B virus variants[43]
| HBV variant | LVD | LdT | ETV | ADV | TDF |
| Wild-type | S | S | S | S | S |
| M204I/V | R | R | I | S | S |
| L180M + M204V | R | R | I | S | S |
| A181T/V | R | R | S | R | I |
| N236T | S | S | S | R | I |
| A181T/V + N236T | R | R | S | R | R |
| L180M + M204V/I ± I179T ± T184G ± S202I/G ± M250I/V | R | R | R | S | S |
HBV: Hepatitis B virus; LVD: Lamivudine; LdT: Telbivudine; ETV: Entecavir; ADV: Adefovir; TDF: Tenofovir; S: Sensitive; I: Intermediate/reduced susceptibility; R: Resistant.
