Table 2.
Studies focusing on liver resection in a context of metabolic syndrome, non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
| Ref. | Endpoint | Underlying parenchyma | Assessment of metabolic factors |
Morbidity |
Mortality | ||
| Overall | Liver related | CV and respiratory | |||||
| Wakai et al[9] | Influence of the underlying liver on liver resection | NAFLD (n = 17) | BMI | 59% | 47% | 6% | 12% |
| Neal et al[10] | Influence of the underlying liver on right trisectionectomy | NASH (n = 9) | All factors | NA | NA | NA | 22% |
| Reddy et al[11] | Influence of the underlying liver on liver resection | Simple steatosis (n = 72) | All factors | 35% | 19% | 28% | 4% |
| NASH (n = 102) | 57% | 28% | 13% | 4% | |||
| Bhayani et al[12] | Influence of the MS on liver resection | NA | MS (n = 256) | 29% | NA | 22% | 6% |
| No MS (n = 3.717) | 23% | 15% | 2% | ||||
| Zarzavadjian Le Bian et al[13] | Influence of the MS on right trisectionectomy | NAFLD (n = 27) | > 2 MS factors (n = 30) | 60% | 53% | NA | 30% |
| ≥ 3 MS factors (n = 13) | NA | NA | NA | 54% | |||
| Cauchy et al[8] | Influence of the MS on liver resection | NASH (n = 16) | MS (n = 62) | 58% | 21%1 | 17%1 | 11% |
1
Major complications: Clavien III-V. MS: Metabolic syndrome; NAFLD: Non-alcoholic fatty liver disease; NASH: Non-alcoholic steatohepatitis; CV: Cardiovascular; NA: Not applicable.