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. 2014 Feb 7;25(6):1226–1235. doi: 10.1681/ASN.2013060665

Figure 1.

Figure 1.

Renalase deficiency aggravates cisplatin AKI. (A) Plasma creatinine levels in WT and renalase KO mice 3 days after administration of cisplatin (n=6, *P<0.05). (B) Left panel: representative photomicrographs for hematoxylin and eosin (H&E) staining of kidney sections of WT mice treated with cisplatin. Middle panel: representative photomicrograph of H&E staining of kidney from renalase KO mice treated with cisplatin. Right panel: renal injury score (n=6, *P<0.05). (C) Left panel: representative photomicrographs of TUNEL staining of kidney sections of WT mice treated with cisplatin (n=6). Middle panel: representative photomicrograph of TUNEL staining of kidney from renalase KO mice treated with cisplatin (n=6). Right panel: number of apoptotic nuclei per ×40 field (n=6, *P<0.05). (D) Left panel: representative photomicrographs of macrophage (F4/80) staining of kidney sections of WT mice treated with cisplatin (n=5). Middle panel: representative photomicrograph of macrophage (F4/80) staining of kidney from renalase KO mice treated with cisplatin (n=5;). Right panel: number of macrophages per ×100 field (n=5, *P<0.05).