Table 3.
Patient characteristics and interphase FISH results according to the presence of MYD88 L265P mutation.
| Characteristics | MYD88 L265P (+) | MYD88 L265P (−) | P* |
|---|---|---|---|
| Age ≥ 65 years | 6/11 (55) | 2/5 (40) | 0.590 |
| Male sex | 9/11 (82) | 3/5 (60) | 0.350 |
| B symptoms | 7/11 (64) | 3/5 (60) | 0.889 |
| Hyperviscosity | 5/11 (46) | 1/5 (20) | 0.330 |
| Splenomegaly | 5/11 (46) | 2/5 (40) | 0.839 |
| Lymphadenopathy | 7/11 (64) | 5/5 (100) | 0.120 |
| Multiple osteolytic lesions | 1/11 (9) | 1/5 (20) | 0.541 |
| Hemoglobin ≤11.5 g/dL | 10/11 (91) | 5/5 (100) | 0.486 |
| Platelet < 100 × 109/L | 2/11 (18) | 2/5 (40) | 0.350 |
| Death | 2/11 (18) | 2/5 (40) | 0.350 |
| IgMκ type monoclonal protein | 10/11 (91) | 3/5 (60) | 0.142 |
| Monoclonal protein (g/dL) | 3.56 (0.50–5.43) | 2.94 (0.55–9.74) | 0.777 |
| PB lymphocytes (×106/L) | 2233 (807–6100) | 1415 (1067–21775) | 0.955 |
| BM lymphocytes (%) | 45.0 (14.4–93.2) | 20.7 (3.0–84.7) | 0.234 |
| BM plasma cells (%) | 3.7 (0–14.0) | 3.2 (0–32.9) | 0.691 |
| BM cellularity (%) | 85 (25–95) | 60 (25–85) | 0.093 |
| High lymphocyte burden in BM biopsy† | 7/11 (64) | 0/5 (0) | 0.017 |
| 6q21 deletion | 6/11 (55) | 0/5 (0) | 0.037 |
| IGH (14q32) translocation | 2/11 (18) | 2/5 (40) | 0.350 |
| P53 (17p13) deletion | 1/11 (9) | 0/5 (0) | 0.486 |
| 1q25 amplification | 0/11 (0) | 1/5 (20) | 0.126 |
| Abnormal karyotype | 3/7 (43) | 2/5 (40) | 0.921 |
BM: bone marrow; FISH: fluorescence in situ hybridization; Ig: immunoglobulin; PB: peripheral blood.
*P values were calculated using χ 2 test for categorical variables and Mann-Whitney U test for continuous variables between patients with or without the MYD88 L265P mutation.
†BM cellularity ≥ 80% with diffuse lymphocytes infiltration in BM biopsy.