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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Biomaterials. 2014 Apr 13;35(21):5453–5461. doi: 10.1016/j.biomaterials.2014.03.055

Fig. 5.

Fig. 5

BMP-2 delivery from GFOGER-functionalized gels improves bone regeneration compared to collagen foams. (A) 3D μCT reconstructions of radii (left) and mineral density sagittal sections (right), scale bar 1 mm. (B) μCT measures of bone volume in radial defects. (C) Bridging score at 8 weeks post-implantation n=13. (D) Maximum torque values for 8 week radial samples subjected to torsion mechanical testing to failure n=5–9. (E) Sections of 8 week radial samples stained with Safranin-O/Fast Green, scale bar 200μm. (F) Retention of infrared dye-labeled BMP-2 at implanted defect site in vivo n=6. (G) Quantification of CD45−/CD90+ osteoprogenitor cells present in defect 7 days post implantation, n=4–6. * p<0.05, ***p<0.001 and ****p<0.0001 compared to Collagen foam/low dose BMP-2.