Table 1.

The residue types observed in TRiC in the two homologous positions to the two marked thermosome residues in figure 2^a.

A	Position 1: Unit α D48		Position 2: Unit β R515		A
	DDDDDDDDDDDDD	D	RRRRRRRRRRRRR	R
B	DDDDDDDDDDDDD	D	RRRRRRRRRRRRR	R	B
G	MMMLLLLLLLLLL	hpb	RRRRRRRRRRRRR	R	G
D	DDDDDDDDDDDDD	D	KKKKKKKRRRKKK	[KR]	D
E	DDDDDDDDDDDDD	D	KKKKKKKKKKKKK	K	E
H	DDDDDDDDDDDDD	D	SSSSSSSSGSSSS	[SG]	H
Q	NNNNNNNNNNNNK	[NK]	RRRSKKRSSSRKR	[RSK]	Q
Z	MMMMVLILILLYL	hpb	LLLLLLLLLLLLL	L	Z

^aFor each subunit and position the data from 13 different organisms are shown in the order: Bovine, Human, Zebrafish, Ciona, Drosophila, C. Elegans, Arabidopsis, Yeast, Neospora, Candida, Dictyostelium, Plasmodium and Paramecium. The amino acids that occur in each row are shown to the right of that row.

^b“hp” is a conserved hydrophobic position.