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. Author manuscript; available in PMC: 2015 Apr 29.
Published in final edited form as: Circulation. 2014 Feb 6;129(17):1770–1780. doi: 10.1161/CIRCULATIONAHA.113.006797

Figure 6.

Figure 6

The effect of CLIC4 on HIF-dependent protein expression and tube formation in HPAECs. Production of (A) ET-1 and (B) VEGF in normoxic and hypoxic HPAECs overexpressing CLIC4 or CLIC4 shRNA (n=3–5). (C) HPAEC tube formation following siRNA-mediated HIF-1α knockdown in cells treated, as indicated (n=5). Each bar represents mean±SEM. *P<0.05; **P<0.01, ***P<0.001 compared with normoxic AdControl; ##P<0.01, ###P<0.001 compared with hypoxic AdControl. Comparisons between AdCLIC4 and CLIC4 shRNA or between scrambled siRNA and HIF-1α siRNA groups are also indicated.