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In vitro cytotoxicity effect on HT-29 cell line after 48 h incubation time of (a) conjugates and free SN38 with different concentrations. Symbols: ■ as SN38-HSA-15, ▲ as SN38-HSA-60, and ◆ as free SN38. (b) Irinotecan with different concentrations. (c) In vitro cytotoxicity of free SN38, SN38-HSA conjugates at 1.6 SN38 equivalent concentration and irinotecan (1.6 μM) compared to vehicle and HSA (n = 6). ***: significantly different with P value < 0.01.
